Our research is focused on elucidating the design principles of cell decision-making1 in multicellular systems2. Single cell decision-making has been a major focus of biology. However, in a multicellular system, cell decisions influence and get influenced by its own micro-environment, consisted of homotypic and heterotypic components. This dialogue makes the system dynamics extremely complex. Decisions of interacting cells allow for the emergence of higher order organizational structures, such as tissues, immune responses, bacterial colonies or tumor. At the same time, the new emergent structures exert selective forces on the cell phenotype decision dynamics. With the aim of understanding the mechanistic connection between single cell decision-making and associated multicellular behavior, we develop multiscale mathematical models. Our philosophy defines our modus operandi when dealing with compex systems medicine problems.
"A good theory makes your data smart"
1. Cellular decision-making: The process whereby cells assume different phenotypes (responses) or fates according to their genetic predisposition or micro-environmental information.
2. Multicellular system: A system that consists from more than one interacting cell to perform all vital functions, such as soft-tissues, immune responses, bacteria colonies or tumors.