**Dr. J. C. L. Alfonso**

Finishing in 2007 my university studies (computer science at the University of La Habana, Cuba), and after five incredible years, I moved to Madrid in 2009 to accomplish my PhD in Mathematics under the supervision of Prof. M. A. Herrero (Department of Applied Mathematics in the Complutense University of Madrid, Spain), Dr. L. Núñez (Head of the Radiophysics Department at the Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain) and Dr. B. García-Archilla (Department of Applied Mathematics at the University of Sevilla, Spain). Moreover, as part of my scientific training I had also the opportunity to work and collaborate with Dr. D. Drasdo and Dr. A. Deutsch, doing research stays of four months (2012 and 2013 respectively) in their research groups.

Once finished my Phd. in 2014, I ended up in Germany at the Center for Advancing Electronics, Technische Universität Dresden. I got a postdoctoral position as a member of the research group led by Dr. H. Hatzikirou 'Multiscale Modeling of Multicellular Systems', and here I am ...

**MAIN RESEARCH INTERESTS:**

- Mathematical problems in radiotherapy and immunotherapy.

- Optimization and numerical simulations of cancer models.

- Modeling and simulation of tumor growth, development and evolution.

- Partial differential equations and dynamical systems in biology.

- Variational problems and calculus of variations.

- Solid and fluid Mechanics.

- Mathematical models in natural sciences.

**SELECTED PUBLICATIONS:**

[5] A. Ramírez-Torres, R. Rodríguez-Ramos, J. Merodio, J. Bravo-Castillero, R. Guinovart-Díaz, J. C. L. Alfonso (2015). “Mathematical modeling of anisotropic tumor growth”. Mech. Res Commun. In press.

[4] A. Ramírez-Torres, R. Rodríguez-Ramos, J. Merodio, J. Bravo-Castillero, R. Guinovart-Díaz, J. C. L. Alfonso (2015). “Action of body forces in tumor growth”. Int. J. Eng. Sci. 89: 18-34.

doi: 10.1016/j.ijengsci.2014.11.009.

[3] J. C. L. Alfonso, N. Jagiella, M. A. Herrero, L. Núñez and D. Drasdo (2014). “Estimating dose painting effects in radiotherapy: a mathematical model”. PLOS ONE 9(2) e89380.

doi: 10.1371/journal.pone.0089380.

[2] J. C. L. Alfonso, G. Buttazzo, B. García-Archilla, M. A. Herrero and L. Núñez (2014). “Selecting radiotherapy dose distributions by means of constrained optimization problems”. Bull Math Biol 76(5): 1017-44. doi:10.1007/s11538-014-9945-7.

[1] J. C. L. Alfonso, G. Buttazzo, B. García-Archilla, M. A. Herrero and L. Núñez (2012). “A class of optimization problems in Radiotherapy dosimetry planning”. Discr. Cont. Dyn. Systems B 17, 6; 1651-1672. doi:10.3934/dcdsb.2012.17.1651.